![]() ![]() Pérez-López FR, Pasupuleti V, Mezones-Holguin E et al (2015) Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Xia J, Song Y, Rawal S et al (2019) Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: a longitudinal study in a multiracial cohort. Zhao X, Fang R, Yu R et al (2017) Maternal Vitamin D Status in the late second trimester and the risk of severe Preeclampsia in Southeastern China. Magnus MC, Miliku K, Bauer A et al (2018) Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study. ![]() Wheeler BJ, Taylor BJ, de Lange M et al (2018) A longitudinal study of 25-hydroxy vitamin D and parathyroid hormone status throughout pregnancy and exclusive lactation in New Zealand mothers and their infants at 45°S. Attention should be paid to the nutritional status of VitD during pregnancy to better prevent the VitD deficiency in neonates.Ĭhang SW, Lee HC (2019) Vitamin D and health-the missing vitamin in humans. ![]() Maternal 25(OH)D concentrations at each trimester were positively associated with neonatal VitD status in cord blood, and the strongest correlation was found in the late stage of pregnancy, which could be considered as a sensitive time window. ![]() Neonatal 25(OH)D level in cord blood was positively correlated with maternal serum 25(OH)D levels at each trimester, and the strongest correlation was found at time point T3. The mean 25(OH)D concentrations at time points T1, T2, T3 in maternal blood and cord blood of the newborns were 26.31 ng/mL, 31.92 ng/mL, 35.62 ng/mL, and 19.77 ng/mL, respectively. Maternal serum 25(OH)D concentrations were measured by LC–MS/MS, and the information on confounding factors was obtained through a standardized questionnaire. Of all the participants, 946 completed the collection of venous blood at early (< 16 weeks, T1), mid- (24–28 weeks, T2), and late (32–34 weeks, T3) pregnancy as well as the corresponding cord blood in the newborns. Participants were pregnant women recruited from the Shanghai Birth Cohort (SBC) ( n = 1100). We aimed to test the associations between maternal VitD status in each of the three trimesters of pregnancy and cord blood 25(OH)D concentrations in newborns. Prenatal vitamin D (VitD) deficiency influences children’s health in later life. ![]()
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